Synthesis and Biological Applications of Schiff Bases: A Short Review

Abstract

Schiff bases are the bimolecular condensation products of carbonyl compounds 
and primary amines. Either an aldehyde or ketone can be the carbonyl 
functional group. Since Schiff bases often contain donor atoms in the forms of 
N and -O, they function as ligands. They have good properties, structural 
resemblances to naturally occurring biological molecules, relatively easy 
preparation methods, and synthetic flexibility that allows for the design of 
appropriate structural scaffolds. The majority of Schiff bases exhibit biological 
properties, including antibacterial, antifungal, antiviral, antimalarial, as well as 
anticancer activity. This review summarizes the synthesis and biological 
activities of Schiff bases.