Antimicrobial Activity of 2-((2- Hydroxybenzylidene) Amino) Nicotinic Acid and Its Cobalt (II) Complexes Synthesized from OPhenylenediamine and 5-Nitrosalisaldehyde

Abstract

Compounds and Cobalt (II) complex of 2-{[(2-
hydroxyphenyl)methylidene]amino} nicotinic acid obtained from ophenylenediamine
and 5-nitrosalicaldehyde were prepared and characterized
using AAS, UV-Visible, IR, 1HNMR, 13CNMR, and GCMS. The synthesized
complex was screened against some microbes in order to establish its potential
antimicrobial activity using some known drugs as references. The results
obtained indicated that, the Schiff Base exhibited antimicrobial action against all
the tested microbes except Candidas albicans isolate, which exhibited zero
diameter zone of inhibition including Escherichia coli, Bacillus subtilis,
Staphylococcus aureus, Klebsiella pneumonia, Enterobacter aeruginosa, and
Proteus mirabilis. It was also found that the synthesized Schiff Base exhibited
two digits purity range, implying that it was relatively stable. The biological
activity of the metal complex of the Schiff Base was found to be comparably
more suiting than that of the synthesized Schiff Base