Isolation and Structure Elucidation of  Quercetin-Derivative (amino-flavone) from  Centaurea perrottetii DC (Asteraceae)

Celestina O. Alebiosu; Mohammed I. Sule; Umar U. Pateh; Mohammed I. Sule; Musa I.  Abdullahi; Aliyu M. Musa; Amina J. Yusuf

doi:10.4314/cajost.v4i2.91

Authors

Celestina O. Alebiosu Department of Pharmaceutical and Medicinal Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria
Mohammed I. Sule Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria
Umar U. Pateh Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria
Mohammed I. Sule
Musa I. Abdullahi
Aliyu M. Musa
Amina J. Yusuf

DOI:

https://doi.org/10.4314/cajost.v4i2.91

Keywords:

Centaurea perrottetii, Quercetin, Amino Flavone.

Abstract

The plant, Centaurea perrottetii DC (Asteraceae) is a herbaceous thistle-like
shrub used in traditional medicine for the treatment of malaria, fever, syphilis,
ulcer and skin infections. The aim of the study is to isolate and elucidate the
structure of compound(s) from C. perrottetii. Quercetin-derivative (an aminoflavone) was isolated from the n-hexane fraction of the methanol extract of the
whole plant of Centaurea perrottetii using a combination of silica gel column and
gel filtration chromatography. The structure of the compound as 2-(3,4-
dihydroxyphenyl)-3-((1-ethylcyclopropyl)amino)-5,7-dihydroxy-4Hchromen-4-
one was established via chemical tests, Ultraviolet (UV), Infrared (IR), 1D- and
2D-dimensional NMR spectroscopy. This is the first report of isolation of this
compound from Centaurea perrottetii